組蛋白在轉錄調控、細胞周期進展和發育事件中起著關鍵作用。組蛋白乙酰化/去乙酰化改變染色體結構并影響轉錄因子對dna的獲取。該基因編碼的蛋白屬于組蛋白去乙酰化酶/acuc/apha家族的Ⅱ類。它包含兩個催化結構域的內部復制，這兩個催化結構域看起來相互獨立。該蛋白具有組蛋白脫乙酰酶活性并抑制轉錄。[由RefSeq提供，2008年7月]
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]