該基因編碼一個含有一個基本螺旋環螺旋結構域和兩個特征性PAS結構域以及一個PAC結構域的蛋白質編碼的蛋白質與配體結合的芳香烴受體結合，并有助于該復合物向細胞核移動，在細胞核中促進參與外源代謝的基因的表達該蛋白也是缺氧誘導因子1轉錄調控的共因子。該位點與12號染色體上的etv6（ets變異體6）基因的染色體易位在白血病中已被描述。選擇性剪接導致多個轉錄變體[由RefSeq提供，2013年10月]
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]