該基因編碼一種結構特異性核酸內切酶，屬于xpf/mus81核酸內切酶家族，在dna鏈間交聯、復制叉折疊和dna雙鏈斷裂后修復過程中對重組中間產物的分解起著關鍵作用。編碼的蛋白質與兩個密切相關的必需的減數分裂內切酶蛋白（eme1或eme2）中的一個結合，形成一個處理dna二級結構的復合物。它包含一個N端DEAH螺旋酶結構域、一個切除修復交叉互補群4（ERCC4）內切酶結構域和兩個串聯的C端螺旋發夾螺旋結構域同源基因純合子敲除的小鼠具有明顯的減數分裂缺陷，包括未能修復DNA雙鏈斷裂的子集[由RefSeq提供，2017年6月]
This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]