CellsandMoleculesinvolvedinlocalacuteinflammatoryresponse
Inflammation has several distinct components, including the localized response at the site of tissue injury or infection. Tissue injury stimulates the release of inflammatory signaling molecules such as bradykinin. Bacterial infection stimulates an immune response in several ways. Bacteria that are phagocytosed can activate macrophages, causing the release of inflammatory cytokines such as IL-1, TNF, and IL-6. Bacter......閱讀全文
Lectin－Induced－Complement－Pathway
The complement cascade of proteolytic factors involved in cellular lysis can be initiated by several different factors, including antibody-dependent a
GDF15基因編碼功能及結構描述
該基因編碼TGFβ（轉化生長因子β）超家族的一個分泌配體這個家族的配體結合各種tgfβ受體，導致調節基因表達的smad家族轉錄因子的募集和激活。編碼的前蛋白經蛋白質水解處理以產生二硫鍵連接的同二聚體的每個亞單位。該蛋白在多種細胞類型中表達，作為一種多效性細胞因子參與細胞損傷后的應激反應增加的蛋白質水
GDF15基因編碼功能及結構描述
該基因編碼TGFβ（轉化生長因子β）超家族的一個分泌配體這個家族的配體結合各種tgfβ受體，導致調節基因表達的smad家族轉錄因子的募集和激活。編碼的前蛋白經蛋白質水解處理以產生二硫鍵連接的同二聚體的每個亞單位。該蛋白在多種細胞類型中表達，作為一種多效性細胞因子參與細胞損傷后的應激反應增加的蛋白質水
GDF15基因突變與藥物因子介紹
該基因編碼TGFβ（轉化生長因子β）超家族的一個分泌配體這個家族的配體結合各種tgfβ受體，導致調節基因表達的smad家族轉錄因子的募集和激活。編碼的前蛋白經蛋白質水解處理以產生二硫鍵連接的同二聚體的每個亞單位。該蛋白在多種細胞類型中表達，作為一種多效性細胞因子參與細胞損傷后的應激反應增加的蛋白質水
CCR3－signaling－in－Eosinophils
Eosinophils are a key class of leukocytes involved in inflammatory responses, including allergic reactions in skin and airway. The eosinophil response
Cell－to－Cell－Adhesion－Signaling
Interactions between cells responsible for cell to cell adhesion also can communicate signals into the cellular interior, often involving interactions
Interleukin6－Induced－Acute－Phenotypic－Microenvironment－Promote...（九）
The strongest and unique “acute” environment induced by cryo-thermal therapy stimulated the most effective anti-tumor immune response?As described
RNAi相關的名詞解釋[英文]
Argonaute?- A family of proteins containing multiple domains and involved in RNA interference (RNAi). Argonatue is the main component of RNAi effector
Growth－Hormone－Signaling－Pathway
Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signa
Aspirin－Blocks－Signaling－Pathway－Involved－in－Platelet－Activation
Activation of the protease-activated GPCRs in platelets contributes to platelet activation in clotting. The protease-activated receptors PAR1 and PAR4
免疫細胞表面抗原分子CD家族對照表(CD1CD247)2
CD1cPositive staining (normal):?subset of normal peripheral B cellsPositive staining (disease):?myeloid leukemias and some B cell malignancies?Negativ
Caspase－Cascade－in－Apoptosis
Apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, a
Ceramide－Signaling－Pathway
Over 1,000 papers and reviews have been written about the role of ceramide in the production of programmed cell death or apoptosis. Ceramide is a sphi
Apoptotic－Signaling－in－Response－to－DNA－Damage
The cellular activation of the caspase cascade resulting in cell death is triggered by chemical damage to DNA which stimulates a sequence resulting in
Monocyte－and－its－Surface－Molecules
Monocytes are a class of phagocytes involved in non-specific immune defense that develop into macrophages. In plasma, monocytes ingest and destroy bac
FAS－signaling－pathway－(－CD95－)
Receptors in the TNF receptor family are associated with the induction of apoptosis, as well as inflammatory signaling. The Fas receptor (CD95) mediat
Corticosteroids－and－cardioprotection
Myocardial infarction damages heart tissue both during the initial ischemia and the subsequent reperfusion of tissues with oxygen. Corticosteroids can
NO2dependent－IL－12－Pathway－in－NK－cells
Macrophages and NK cells help provide innate immunity against infection by intracellular parasites and communicate with each other to regulate this pr
B－Lymphocyte－Cell－Surface－Molecules
B cells must communicate with their environment to participate in the immune system as the source of antigen-specific immunoglobulins. Cell surface pr
IRF1基因編碼功能及結構描述
該基因編碼的蛋白質是一種轉錄調節因子和腫瘤抑制因子，是參與先天性和獲得性免疫應答的基因激活因子。編碼的蛋白質激活參與機體對病毒和細菌反應的基因轉錄，在細胞增殖、凋亡、免疫反應和DNA損傷反應中發揮作用這種蛋白質抑制其他幾個基因的轉錄。作為一種抑癌劑，它既抑制腫瘤細胞的生長，又刺激對腫瘤細胞的免疫反應
IRF1基因突變與藥物因子介紹
該基因編碼的蛋白質是一種轉錄調節因子和腫瘤抑制因子，是參與先天性和獲得性免疫應答的基因激活因子。編碼的蛋白質激活參與機體對病毒和細菌反應的基因轉錄，在細胞增殖、凋亡、免疫反應和DNA損傷反應中發揮作用這種蛋白質抑制其他幾個基因的轉錄。作為一種抑癌劑，它既抑制腫瘤細胞的生長，又刺激對腫瘤細胞的免疫反應
IRF1基因編碼功能及結構描述
該基因編碼的蛋白質是一種轉錄調節因子和腫瘤抑制因子，是參與先天性和獲得性免疫應答的基因激活因子。編碼的蛋白質激活參與機體對病毒和細菌反應的基因轉錄，在細胞增殖、凋亡、免疫反應和DNA損傷反應中發揮作用這種蛋白質抑制其他幾個基因的轉錄。作為一種抑癌劑，它既抑制腫瘤細胞的生長，又刺激對腫瘤細胞的免疫反應
Determination－and－Detection－of－Reactive－Oxygen－Species－(ROS),－Lipid－...
Reactive oxygen species or intermediates are formed by the incomplete reduction of oxygen. Organisms living in aerobic environment generate variou
B－Cell－Receptor－Complex
B cells produce immunoglobulins (Ig, antibodies) that specifically bind antigen molecules. B cells first produce a membrane-bound form of immunoglobul
T－Cell－Receptor－and－CD3－Complex
The T cell receptor is a cell-surface receptor that recognizes specific antigen to stimulate the T cell response to that antigen. The T cell receptor
Complement－Pathway
The complement pathway consists of a series of over thirty proteins in plasma that are part of the immune response. Activation of the complement syste
The－41BBdependent－immune－response
The activation of T cells requires a co-stimulatory signal with T cell receptor activation, provided in many cases by activation of CD28 in resting T
IL10－Antiinflammatory－Signaling－Pathway
IL-10 is a cytokine with potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-alpha, IL-6 and IL-1 by
Glycolysis－Pathway
Glycolysis was one of the first metabolic pathways studied and is one of the best understood, in terms of the enzymes involved, their mechanisms of ac
ChREBP－regulation－by－carbohydrates－and－cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans